Clashes between Roma and Manchester United fans in the vicinity of the Stadio Olimpico occurred prior the game while baton-wielding riot police laid into United fans inside the stadium after trouble broke out during the match.
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Terror on the terraces: blood pours from the head of a Manchester United supporter in Rome's Olympic Stadium as fans clash with police
A spokesman for the police department in Rome said: "Sixteen of the fans were discharged while two of the fans will remain in hospital overnight. However, they are not in serious condition." Two Roma fans were also taken to hospital.
An estimated 4,000 Manchester United fans travelled to Rome for the quarter-final first-leg tie. Man Utd had anticipated problems and had issued a statement on their website warning their fans to be careful.
Fans threw missiles at each other before the start of the game and the tension soon returned after Man Utd midfielder Paul Scholes was sent off shortly after the half-hour mark.
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Riot police square off against the red shirts of Manchester United fans in the Stadio Olimpico this evening
Trouble escalated after Roma took a 43rd-minute lead, with the Italian police storming the Manchester United fans section, using batons against the visiting fans.
United's travelling support were only allowed to leave the stadium 90 minutes after the game under police escort.
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BBC Five Live commentator Alan Green, who witnessed the trouble, said: "United fans appeared to charge the police and the police went in. It got pretty vicious.
"We're about 80 yards away but it seems to have quietened down now. We've just heard a loud crash and there is smoke over there. It is very, very nasty inside this ground now.
"I don't know if the Roma fans started this but they are happy now as it is between the police and the United fans."
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Seats were being thrown as Manchester United fans squared off against the riot police
Earlier around 300 English fans were involved in a stand-off before the first leg quarter final tie.
Three Middlesbrough fans were stabbed and 10 others hurt during fights with Roma fans at the Uefa quarter finals last year.
Meanwhile, announcements were made over the public address system threatening to halt the game. On the pitch Paul Scholes was sent off just 33 minutes into the match.
UEFA today launched an urgent investigation into the crowd trouble.
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