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Aspirin offers bowel cancer hope
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11 January 2007
Researchers found taking a daily dose of 300mg or more of aspirin for five years can prevent colorectal cancer later in life.
Incidence of bowel cancer was reduced by up to 74% a decade to 15 years after the treatment was started.
The cancer typically takes at least 10 years to develop from pre-cancerous growths in the gut.
Except in special circumstances, doctors generally advise against long-term aspirin use because of the risk of serious side effects such as internal bleeding and stomach ulcers.
But the authors of the new study, reported in The Lancet medical journal, say in the case of people with a higher-than-average risk of bowel cancer the benefits may outweigh the risks.
Each year, around 35,000 men and women in the UK are diagnosed with bowel cancer, and more than 16,000 die from the disease.
The new research, led by Professor Peter Rothwell from Radcliffe Infirmary, Oxford, revisited patients from two large aspirin trials conducted in the late 1970s and early 1980s.
The aim was to see if regularly taking aspirin had any delayed effect on bowel cancer rates.
Using aspirin for five years was found to reduce the subsequent incidence of bowel cancer by 37% overall, and 74% during the period 10 to 15 years after the trials started.
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