Desperate Housewives star Jesse Metcalfe in late-night brawl after split from Nadine Coyle

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The actor reportedly got into a fist fight with the boyfriend of a C-list actress outside Boulevard 3 nightclub in Hollywood last night.

Jesse, 29, came off second best in the brawl and ended up hitting the pavement after being punched in the face.

According to one US website, Jesse spotted a friend of his, actress Taryn Manning, and strolled over for a chat and a hug.

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Up close and personal: Things get heated as the man grabs Jesse around the throat last night

On the ropes: Jesse's not faring well as his opponent shakes him by the throat

Fists flying: The brawlers have to be separated again

Over and out: Jesse Metcalfe bites the dust during the fight

Time out: A club doorman steps in between the warring pair

This didn't sit too well with Taryn's partner, who launched into such a frenzied attack against Jesse that doormen had to step in and part the two men.

While Jesse seems to be struggling since the breakdown of his rocky two-year relationship with Nadine, it seems his ex is not faring so badly.

Sources say Nadine is embracing life as a single girl, as well as providing a shoulder to cry on for fellow band mate Cheryl Cole.

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Happier times: Nadine and Jesse before the split