The Oscar-winning actress will appear in Cries From The Heart at the Royal Court Theatre, a one-off production in aid of Human Rights Watch.
Christie, 66, last appeared on the British stage in a revival of Harold Pinter's Old Times in 1995.
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After 12 years away, Julie Christie is set to star in Cries From The Heart
Cries From The Heart is an evening of performances featuring some of Britain's foremost acting talent.
Christie will be joined by the likes of Jeremy Irons, Sinead Cusack, Tom Stoppard, Sophie Okonedo, Juliet Stevenson and Dame Eileen Atkins. Journalists George Alagiah, Fergal Keane and Rageh Omaar will also take part.
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Julie Christie in the classic drama Dr Zhivago
Julie Christie, once a West End favourite, is set to return to the stage
She will also read poems by Raymond Carver, Leon Laleau and Polish Nobel Laureate Wislawa Symborska.
The actress won an Oscar in 1965 for Darling.
Her film career has included acclaimed performances in The Go-Between, Doctor Zhivago, Billy Liar, Don't Look Now and Finding Neverland.
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