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The Premiership pair, through to the last eight for the first time, will be guaranteed an English venue should they reach the last four.

Irish, provided they repeat theirhomepool win over Perpignan, would face Toulouse or Cardiff, while Saracens are in line to take on Gloucester or Munster.

Tuesday's draw also gave the Ospreys an extra incentive to ruin such a prospect at Twickenham, with the promise of securing a semi-final at the Millennium Stadium in late April, just a month before the final at the same venue.

If the Swansea-based regional team knock out Saracens at Vicarage Road in the quarter-final on April 6 their reward will be a 'home' tie in Wales against Gloucester or Munster.

Within hours of the draw being made Toulouse had been installed as clear 7-4 favourites, with Munster behind them in the betting at 5-1.

Cardiff, closer to their first final than at any time since the inaugural season 12 years ago, will have to get there the hard way.

If they survive the quarter-final in Toulouse, they could easily find themselves back in France three weeks later for a semi against Perpignan.

Leicester and England prop Julian White and three London Irish forwards, flanker Declan Danaher, replacement prop Dan Murphy and second-row Bob Casey, have been cited for alleged foul play in Saturday's Cup matches.

HEINEKEN CUP QTR-FINALS Saturday, April 5 London Irish v Perpignan (3.0). Gloucester v Munster (5.30).

Sunday, April 6 Saracens v Ospreys (12.30). Toulouse v Cardiff (3.0).

Semi-finals April 26 or 27 London Irish or Perpignan v Toulouse or Cardiff. Saracens or Ospreys v Gloucester or Munster.