Roma captain Totti out of United Champions League clash

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Totti played the full 90 minutes of Roma's 1-1 draw at Cagliari on Saturday with heavy strapping on his knee but was spotted clutching the back of his left thigh several times.

Down and out: Totti will miss Tuesday's Champions League clash with United

And the club later confirmed Totti will miss Tuesday's quarter-final first-leg tie in Rome and is a major doubt for the return leg at Old Trafford on April 9.

"At the end of yesterday's encounter, Francesco Totti complained of a pain in the flexor of his left thigh,' said a club statement.

"In the morning of Sunday March 30 he was subjected to tests that highlighted a muscular injury in the cavity of the left thigh flexor. The player will have to have a period of rest and the situation will be monitored over the next few days."

Totti's loss is a big blow to Italy's sole Champions League survivor. He is their top scorer in Serie A this term with 14 goals and he picked up the European Golden Boot last season with 26 league strikes.

The injury is also a major blow to Roma's Serie A title ambitions. They currently trail leaders Inter Milan by four points.