Nadal crashes out

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The 15th-seeded Ferrer defeated the tournament's second seed 6-7 6-4 7-6 6-2 in a fourth-round encounter that lasted three hours and 38 minutes and ended at 1.50am local time.

Ferrer will now go on to play 20th seed Juan Ignacio Chela in the quarter-finals.

Nadal, who has never advanced past the quarter-finals in the New York grand slam event, has been battling tendinitis in his left knee but was not looking for excuses.

Nadal said: "It's disappointing for me, but that is part of the sport. I gave 100%.

"I prefer that I don't speak about my body right now because I don't want to make an excuse.

"[Ferrer] is a very tough player. He's having an unbelievable season."

The aggressive Ferrer prevailed and broke Nadal seven times on the night with his final break sealing what may be the biggest victory of his career.

Ferrer equals his best Grand Slam performance by reaching the last eight, a feat he accomplished at the French Open in 2005.

The 25-year old is one of two Spanish players remaining in the draw along with 17th seed Carlos Moya, who overcame unseeded Ernests Gulbis.