Top two clash in FA Cup

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The two sides have been doing battle at the top of the Barclays Premier League for much of the season and their meeting at Old Trafford means at least one of the remaining six top-flight sides will drop out before the next stage.

Holders Chelsea have been drawn against Coca-Cola League One side Huddersfield at Stamford Bridge, while Liverpool have a home draw with Barnsley.

The other two Premier League sides have both been handed trips to second-tier opposition, with Middlesbrough travelling to Manchester City's conquerors Sheffield United and Portsmouth visiting Preston, who hammered Derby in the fourth round.

The draw is completed by Coventry versus West Brom, Cardiff against Wolves and Southampton's visit to the bottom-ranked team in the draw, Bristol Rovers.