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Almost 58,000 fans managed to defy the strike and make it to Wembley to see England thrash Andorra 6-0.
Wembley Park Tube station was running a reduced service after last night's match but staff said the majority of fans got trains before the station closed at 11.30pm.
Fans were warned of "serious" road congestion, with no extra parking being laid on, and bus services expected to be delayed.
Most of the difficulties were before kick-off as overground trains were withdrawn because of fears of overcrowding.
Transport Commissioner Peter Hendy said: "I am delighted that we were able to help so many fans get to and from the game safely.
"Despite the RMT strike, we provided Tube services on three lines and laid on many extra bus services after the game. I also want to thank fans for their patience."
